Sulphamic Acid

Description

Sulfamic acid, also known as amidosulfonic acid, amidosulfuric acid, aminosulfonic acid, and sulfamidic acid, is a molecular compound with the formula H3NSO3. This colorless, water-soluble compound finds many applications.
Sulfamic acid is a member of the following series of compounds: H2SO4 (sulfuric acid), H3NSO3 (sulfamic acid), H4N2SO2 (sulfamide), H5N3SO (unknown), and , H6N4S (unknown).
Applications
The most famous applicaton of sulfamic acid is in the synthesis of compounds that taste sweet. Reaction with cyclohexylamine followed by addition of NaOH gives C6H11NHSO3Na, sodium cyclamate. Related compounds are also sweetners, see acesulfame potassium.
Dulfamates (O-substituted-, N-substituted-, or di-/tri-substituted derivatives of sulfamic acid) have been used in the design of many types of therapeutic agents such as antibiotics, nucleoside/nucleotide human immunodeficiency virus (HIV) reverse tanscriptase inhibitors, HIV protease inhibitors (PIs), anti-cancer drugs (steroid sulfatase and carbonic anhydrase inhibitors), anti-epileptic drugs, and weight loss drugs.
Sulfamic acid is used as an acidic cleaning agent, typically for metals and ceramics. It is a replacement for hydrochloric acid for the removal of rust.
· Catalyst for esterification process
· Dye and pigment manufacturing
· Herbicide
· Coagulator for urea-formaldehyde resins
· Ingredient in fire extinguishing media
· Pulp and paper industry as a chloride stabilizer
· Synthesis of nitrous oxide by reaction with nitric acid

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